A noncovalent, fluoroalkyl coating monomer for phosphonate-covered nanoparticles.

ABSTRACT: Gadolinium-containing phosphonate-coated gold nanoparticles were prepared and then non-covalently coated with an amphiphilic fluorous monomer. The monomer spontaneously self-assembles into a non-covalent monolayer shell around the particle. The binding of the shell utilizes a guanidinium-phosphonate interaction analogous to the one exploited by the Wender molecular transporter system. Particle-shell binding was characterized by a 27% decrease in ¹⁹F T₁ of the fluorous shell upon exposure to the paramagnetic gadolinium in the particle and a corresponding increase in hydrodynamic diameter from 3 nm to 4 nm. Interestingly, a much smaller modulation of ¹⁹F T₁ is observed when the shell monomer is treated with a phosphonate-free particle. By contrast,

SUBMITTER: Li V 

PROVIDER: S-EPMC3728910 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature