Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor.

ABSTRACT: To date, five human metabotropic glutamate (mGlu) 1 receptor splice variants (1a, 1b, 1d, 1f, and 1g) have been described, all of which involve alternative C-terminal splicing. mGlu1a receptor contains a long C-terminal domain (341 amino acids), which has been shown to scaffold with several proteins and contribute to the structure of the post-synaptic density. However, several shorter mGlu1 receptor splice variants lack the sequence required for these interactions, and no major functional differences between these short splice variants have been described. By using RT-PCR we have shown that two human melanoma cell lines express both mGlu1a and mGlu1b receptors. In addition, using 3'RACE, we identified three previously unknown mGlu1 receptor mRNAs. Two differ in the length of their 3' untra

SUBMITTER: DiRaddo JO 

PROVIDER: S-EPMC3729114 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature