Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus.

ABSTRACT: Necator americanus is the major cause of human hookworm infection, which is a global cause of anemia in the developing world. Ongoing efforts to control hookworm infection include the identification of candidate vaccine antigens as well as potential therapeutic targets from the infective L3 larval stages and adult stages of the parasite. One promising family of proteins are the adult-stage-secreted cytosolic glutathione S-transferases (GSTs). Nematode GSTs facilitate the inactivation and degradation of a variety of electrophilic substrates (drugs) via the nucleophilic addition of reduced glutathione. Parasite GSTs also play significant roles in multi-drug resistance and the modulation of host immune defense mechanisms. Here, the structure of Na-GST-3, one of three GSTs secreted by adult-st

SUBMITTER: Kelleher A 

PROVIDER: S-EPMC3729155 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature