Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex.

ABSTRACT: Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.

SUBMITTER: Mohandessi S 

PROVIDER: S-EPMC3729426 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature