Monoclonal antibody humanness score and its applications.

ABSTRACT:

Background

Monoclonal antibody therapeutics are rapidly gaining in popularity for the treatment of a myriad of diseases, ranging from cancer to autoimmune diseases and neurological diseases. Multiple forms of antibody therapeutics are in use today that differ in the amount of human sequence present in both the constant and variable regions, where antibodies that are more human-like usually have reduced immunogenicity in clinical trials.

Results

Here we present a method to quantify the humanness of the variable region of monoclonal antibodies and show that this method is able to clearly distinguish human and non-human antibodies with excellent specificity. After creating and analyzing a database of human antibody sequences, we conducted an in-depth analysis of the humanness o

SUBMITTER: Gao SH 

PROVIDER: S-EPMC3729710 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature