SnoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

ABSTRACT: Amplification of the MYCN oncogene is strongly associated with poor prognosis in neuroblastoma (NB). In addition to MYCN amplification, many studies have focused on identifying patients with a poor prognosis based on gene expression profiling. The majority of prognostic signatures today are comprised of large gene lists limiting their clinical application. In addition, although of prognostic significance, most of these signatures fail to identify cellular processes that can explain their relation to prognosis. Here, we determined prognostically predictive genes in a data set containing 251 NBs. Gene Ontology analysis was performed on significant genes with a positive hazard ratio to search for cellular processes associated with poor prognosis. An enrichment in ribonucleoproteins (RNPs) was

SUBMITTER: von Stedingk K 

PROVIDER: S-EPMC3730020 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature