Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.

ABSTRACT:

Background

The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL1-negative) chronic myeloid leukemia (CML), both of which are diagnosed on the basis of neoplastic expansion of granulocytic cells and exclusion of genetic drivers that are known to occur in other myeloproliferative neoplasms and myeloproliferative-myelodysplastic overlap neoplasms.

Methods

To identify potential genetic drivers in these disorders, we used an integrated approach of deep sequencing coupled with the screening of primary leukemia cells obtained from patients with CNL or atypical CML against panels of tyrosine kinase-specific small interfering RNAs or small-molecule kinase inhibitors. We validated candidate o

SUBMITTER: Maxson JE 

PROVIDER: S-EPMC3730275 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature