Toward genome-wide identification of Bateson-Dobzhansky-Muller incompatibilities in yeast: a simulation study.

ABSTRACT: The Bateson-Dobzhansky-Muller (BDM) model of reproductive isolation by genetic incompatibility is a widely accepted model of speciation. Because of the exceptionally rich biological information about the budding yeast Saccharomyces cerevisiae, the identification of BDM incompatibilities in yeast would greatly deepen our understanding of the molecular genetic basis of reproductive isolation and speciation. However, despite repeated efforts, BDM incompatibilities between nuclear genes have never been identified between S. cerevisiae and its sister species S. paradoxus. Such negative results have led to the belief that simple nuclear BDM incompatibilities do not exist between the two yeast species. Here, we explore an alternative explanation that such incompatibilities exist but were undetect

SUBMITTER: Li C 

PROVIDER: S-EPMC3730343 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature