Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid.

ABSTRACT: Reduced estrogens, either through aging or postsurgery breast cancer treatment with the oral nonsteroidal aromatase inhibitor letrozole, are linked with declined cognitive abilities. However, a direct link between letrozole and neuronal deficits induced by pathogenic insults associated with aging such as beta amyloid (Aβ 1-42) has not been established. The objective of this study was to determine if letrozole aggravates synaptic deficits concurrent with Aβ 1-42 insult. We examined the effects of letrozole and oligomeric Aβ 1-42 treatment in dissociated and organotypic hippocampal slice cultures. Changes in glial cell morphology, neuronal mitochondria, and synaptic structures upon letrozole treatment were monitored by confocal microscopy, as they were shown to be affected by Aβ 1-42 oligome

SUBMITTER: Chang PK 

PROVIDER: S-EPMC3730361 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature