A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells.

ABSTRACT: Embryonic stem cells (ESCs) differentiate in vivo and in vitro into all cell lineages, and they have been proposed as cellular therapy for human diseases. However, the molecular mechanisms controlling ESC commitment toward specific lineages need to be specified. We previously found that the p38 mitogen-activated protein kinase (p38MAPK) pathway inhibits neurogenesis and is necessary to mesodermal formation during the critical first 5 days of mouse ESC commitment. This period corresponds to the expression of specific master genes that direct ESC into each of the three embryonic layers. By both chemical and genetic approaches, we found now that, during this phase, the p38MAPK pathway stabilizes the p53 protein level and that interfering directly with p53 mimics the effects of p38MAPK inhibit

SUBMITTER: Hadjal Y 

PROVIDER: S-EPMC3730419 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature