A network of HMG-box transcription factors regulates sexual cycle in the fungus Podospora anserina.

ABSTRACT: High-mobility group (HMG) B proteins are eukaryotic DNA-binding proteins characterized by the HMG-box functional motif. These transcription factors play a pivotal role in global genomic functions and in the control of genes involved in specific developmental or metabolic pathways. The filamentous ascomycete Podospora anserina contains 12 HMG-box genes. Of these, four have been previously characterized; three are mating-type genes that control fertilization and development of the fruit-body, whereas the last one encodes a factor involved in mitochondrial DNA stability. Systematic deletion analysis of the eight remaining uncharacterized HMG-box genes indicated that none were essential for viability, but that seven were involved in the sexual cycle. Two HMG-box genes display striking features

SUBMITTER: Ait Benkhali J 

PROVIDER: S-EPMC3730723 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature