Stabilizing selection, purifying selection, and mutational bias in finite populations.

ABSTRACT: Genomic traits such as codon usage and the lengths of noncoding sequences may be subject to stabilizing selection rather than purifying selection. Mutations affecting these traits are often biased in one direction. To investigate the potential role of stabilizing selection on genomic traits, the effects of mutational bias on the equilibrium value of a trait under stabilizing selection in a finite population were investigated, using two different mutational models. Numerical results were generated using a matrix method for calculating the probability distribution of variant frequencies at sites affecting the trait, as well as by Monte Carlo simulations. Analytical approximations were also derived, which provided useful insights into the numerical results. A novel conclusion is that the scal

SUBMITTER: Charlesworth B 

PROVIDER: S-EPMC3730922 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature