Genetic mapping of specific interactions between Aedes aegypti mosquitoes and dengue viruses.

ABSTRACT: Specific interactions between host genotypes and pathogen genotypes (G×G interactions) are commonly observed in invertebrate systems. Such specificity challenges our current understanding of invertebrate defenses against pathogens because it contrasts the limited discriminatory power of known invertebrate immune responses. Lack of a mechanistic explanation, however, has questioned the nature of host factors underlying G×G interactions. In this study, we aimed to determine whether G×G interactions observed between dengue viruses and their Aedes aegypti vectors in nature can be mapped to discrete loci in the mosquito genome and to document their genetic architecture. We developed an innovative genetic mapping strategy to survey G×G interactions using outbred mosquito families that were exper

SUBMITTER: Fansiri T 

PROVIDER: S-EPMC3731226 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature