Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC3731568 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Wu Jianfeng J Huang Zhe Z Ren Junming J Zhang Zhirong Z He Peng P Li Yangxin Y Ma Jianhui J Chen Wanze W Zhang Yingying Y Zhou Xiaojuan X Yang Zhentao Z Wu Su-Qin SQ Chen Lanfen L Han Jiahuai J
Cell research 20130709 8
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines. We have generated Mlkl-deficient mice by transcription activator-like effector nucleases (TALENs)-mediated gene disruption and found Mlkl to be dispensable for normal mouse development as well as immune cell development. Mlkl-deficient mouse embryonic fibrobla ...[more]