Asthma and atopic dermatitis are associated with increased risk of clinical Plasmodium falciparum malaria.

ABSTRACT:

Objectives

To assess the impact of atopy and allergy on the risk of clinical malaria.

Design

A clinical and immunological allergy cross-sectional survey in a birth cohort of 175 children from 1 month to 14 years of age followed for up to 15 years in a longitudinal open cohort study of malaria in Senegal. Malaria incidence data were available for 143 of these children (aged 4 months to 14 years of age) for up to 15 years. Mixed-model regression analysis was used to determine the impact of allergy status on malaria incidence, adjusting for age, gender, sickle-cell trait and force of infection.

Main outcome measures

Asthma, allergic rhinoconjunctivitis and atopic dermatitis status, the number of clinical Plasmodium falciparum malaria episodes since birth and associated p

SUBMITTER: Herrant M 

PROVIDER: S-EPMC3731724 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature