Randomised, double-blind controlled trial by dose reduction of implanted intrathecal morphine delivery in chronic non-cancer pain.

ABSTRACT:

Objective

This study aimed to investigate the efficacy of intrathecal morphine in the long term by hypothesising that a reduction of the intrathecal opioid dose following long-term administration would increase the level of pain intensity.

Design

Randomised, double-blind, controlled, parallel group trial.

Setting

Department of Pain Management, Russells Hall Hospital, Dudley, UK.

Participants

24 patients with non-cancer pain implanted with morphine reservoirs were assessed for eligibility.

Interventions

Participants were randomly allocated to one of two parallel groups in which one of the groups had no change in morphine dose and the other group had a small reduction (20%) in dosage every week during a 10-week follow-up.

Outcome

Primary outcomes we

SUBMITTER: Raphael JH 

PROVIDER: S-EPMC3731763 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature