Trajectory of intensive treat-to-target disease modifying drug regimen in an observational study of an early rheumatoid arthritis cohort.

ABSTRACT: Studies of early rheumatoid arthritis (RA) cohorts have analysed treatment response and prognostic factors at fixed time points. However, in treat-to-target protocols, therapeutic decision-making is dynamic and responsive to disease activity over time. To determine when a minimal residual disease response target should be expected, our primary objective was to identify the time-dependent therapeutic response to combination disease modifying antirheumatic drugs (DMARDs) for 12 months. Our secondary objective determined factors affecting this response trajectory. Observational cohort. Treat-to-target early RA clinic in Australian tertiary referral hospital. We enrolled consecutive patients attending an early arthritis clinic with symptom duration less than 12 months, who were diagnosed with

SUBMITTER: White D 

PROVIDER: S-EPMC3731780 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature