TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy.

ABSTRACT: Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers simultaneously could result in better therapeutic efficacy. We created a functional chimeric antigen receptor-the TanCAR, a novel artificial molecule that mediates bispecific activation and targeting of T cells. We demonstrate the feasibility of cumulative integration of structure and docking simulation data using computational tools to interrogate the design and predict the functionality of such a complex bispecific molecule. Our prototype TanCAR induced distinct T cell reactivity against each of two tumor restricted antigens, and produced syn

SUBMITTER: Grada Z 

PROVIDER: S-EPMC3731887 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature