Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE).

ABSTRACT: Pathology consensus review for clinical trials and disease classification has historically been performed by manual light microscopy with sequential section review by study pathologists, or multi-headed microscope review. Limitations of this approach include high intra- and inter-reader variability, costs, and delays for slide mailing and consensus reviews. To improve this, the Nephrotic Syndrome Study Network (NEPTUNE) is systematically applying digital pathology review in a multicenter study using renal biopsy whole slide imaging (WSI) for observation-based data collection. Study pathology materials are acquired, scanned, uploaded, and stored in a web-based information system that is accessed through a web-browser interface. Quality control includes metadata and image quality review. Ini

SUBMITTER: Barisoni L 

PROVIDER: S-EPMC3731905 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature