Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients.

ABSTRACT:

Background and objectives

Arteriovenous fistula (AVF) failure remains an important cause of morbidity in hemodialysis patients. The exact underlying mechanisms responsible for AVF failure are unknown but processes like proliferation, inflammation, vascular remodeling, and thrombosis are thought to be involved. The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large population of incident hemodialysis patients.

Design, setting, participants, & measurements

A total of 479 incident hemodialysis patients were included between January 1997 and April 2004. Follow-up lasted 2 years or until AVF failure, defined as surgery, percutaneous endovascular interve

SUBMITTER: Verschuren JJ 

PROVIDER: S-EPMC3731912 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature