Susceptibility loci associated with prostate cancer progression and mortality.

ABSTRACT:

Purpose

Prostate cancer is a heterogeneous disease with a variable natural history that is not accurately predicted by currently used prognostic tools.

Experimental design

We genotyped 798 prostate cancer cases of Ashkenazi Jewish ancestry treated for localized prostate cancer between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to clinical data. The survival analysis was adjusted for Gleason score and prostate-specific antigen. We investigated associations between 29 single nucleotide polymorphisms (SNP) and biochemical recurrence, castration-resistant metastasis, and prostate cancer-specific survival. Subsequently, we did an independent analysis using a high-resolution panel of 13 SNPs.

Resu

SUBMITTER: Gallagher DJ 

PROVIDER: S-EPMC3732009 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature