Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.

ABSTRACT:

Background

Phototransduction in vertebrate photoreceptor cells represents a paradigm of signaling pathways mediated by G-protein-coupled receptors (GPCRs), which share common modules linking the initiation of the cascade to the final response of the cell. In this work, we focused on the recovery phase of the visual photoresponse, which is comprised of several interacting mechanisms.

Results

We employed current biochemical knowledge to investigate the response mechanisms of a comprehensive model of the visual phototransduction pathway. In particular, we have improved the model by implementing a more detailed representation of the recoverin (Rec)-mediated calcium feedback on rhodopsin kinase and including a dynamic arrestin (Arr) oligomerization mechanism. The model was succes

SUBMITTER: Invergo BM 

PROVIDER: S-EPMC3732082 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature