Association between the XRCC6 Promoter rs2267437 polymorphism and cancer risk: evidence based on the current literature.

ABSTRACT:

Background

Increasing evidence suggests that the DNA repair gene XRCC6 (Ku70) may be critically involved in the aetiology of the human carcinogenesis. Many studies have investigated the association between the rs2267437 polymorphism and cancer susceptibility. However, the results of these studies have been controversial. This meta-analysis was conducted to quantitatively summarize the evidence for a relationship between the rs2267437 polymorphism and cancer risk.

Methods

Electronic databases, including PUBMED and EMBASE, were searched for publications that met the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between the XRCC6 promoter rs2267437 polymorphism and cancer risk in a fixed-effe

SUBMITTER: Xu H 

PROVIDER: S-EPMC3732414 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature