Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement.

ABSTRACT:

Background

In contrast to the prominent function of the blood vasculature in promoting tissue inflammation, the role of lymphatic vessels in inflammation has been scarcely studied in vivo. To investigate whether modulating lymphatic vessel function might affect the course of chronic inflammation, the major lymphangiogenic receptor, vascular growth factor receptor 3 (VEGFR-3, FLT4), was blocked in an established model of inflammatory bowel disease.

Methods

Interleukin 10 (IL10)-deficient mice that spontaneously develop inflammatory bowel disease were treated with a blocking antibody to VEGFR-3 for 18 days, and the inflammatory changes in colon tissue and the blood and lymphatic vascularization were quantitatively analyzed.

Results

We found a significant increase in the

SUBMITTER: Jurisic G 

PROVIDER: S-EPMC3732464 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature