Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression.

ABSTRACT:

Background

The anterior hippocampus is associated with emotional functioning and hippocampal volume is reduced in depression. More women are clinically depressed than men, yet the depressed female brain is little studied. We reported reduced anterior hippocampal volume in behaviorally depressed adult female cynomolgus macaques; the mechanisms contributing to that reduction are unknown. The present study represents the first systematic morphological investigation of the entire hippocampus in depressed female primates.

Methods

Cellular determinants of hippocampal size were examined in subregions of anterior and posterior hippocampus in antidepressant-naïve, adult female monkeys characterized for behavioral depression and matched on variables that influence hippocampal size (n

SUBMITTER: Willard SL 

PROVIDER: S-EPMC3732810 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature