Intrinsic connectivity network disruption in progressive supranuclear palsy.

ABSTRACT:

Objective

Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific network targeted has not been fully characterized. We sought to delineate the affected network in patients with clinical PSP.

Methods

Using task-free functional magnetic resonance imaging, we mapped intrinsic connectivity to the dorsal midbrain tegmentum (dMT), a region that shows focal atrophy in PSP. Two healthy control groups (1 young, 1 older) were used to define and replicate the normal connectivity pattern, and patients with PSP were compared to an independent matched healthy control group on measures of network connectivity.

Results

Healthy young and older subjects showed a convergent pattern of connectivity to the dMT, including brainste

SUBMITTER: Gardner RC 

PROVIDER: S-EPMC3732833 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature