Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.

ABSTRACT: The success of tissue regenerative therapies is contingent on functional and multicellular vasculature within the redeveloping tissue. Although endothelial cells (ECs), which compose the vasculature's inner lining, are intrinsically able to form nascent networks, these structures regress without the recruitment of pericytes, supporting cells that surround microvessel endothelium. Reconstruction of typical in vivo microvascular architecture traditionally has been done using distinct cell sources of ECs and pericytes within naturally occurring matrices; however, the limited sources of clinically relevant human cells and the inherent chemical and physical properties of natural materials hamper the translational potential of these approaches. Here we derived a bicellular vascular population fr

SUBMITTER: Kusuma S 

PROVIDER: S-EPMC3732921 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature