Identification of multiple RIG-I-specific pathogen associated molecular patterns within the West Nile virus genome and antigenome.

ABSTRACT: The ability of viruses to control and/or evade the host antiviral response is critical to the establishment of a productive infection. One of the strategies utilized by West Nile virus (WNV) to circumvent the host response is to evade detection by the pathogen recognition receptor RIG-I early in infection. To begin elucidating the mechanisms by which WNV eludes detection, we undertook a systematic analysis of the WNV genome and antigenome to identify RIG-I-specific pathogen associated molecular patterns (PAMPs). Multiple segments of the WNV genome and anitigenome induced a RIG-I-specific antiviral response. However, incorporation of the stimulatory regions into larger RNAs substantially reduced their capacity to activate RIG-I. These results suggested that WNV evades the host response by s

SUBMITTER: Shipley JG 

PROVIDER: S-EPMC3733099 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature