Screening for hypothalamic-pituitary-adrenal axis suppression in asthmatic children remains problematic: a cross-sectional study.

ABSTRACT:

Objective

To determine which parameter is the most useful screening test for hypothalamic-pituitary-adrenal suppression in asthmatic children.

Design

Cross-sectional study.

Setting

Paediatric allergy clinics in Cape Town, South Africa.

Participants

143 asthmatic children of mostly mixed ancestry, aged 5-12 years.

Outcome measures

Primary outcome measures included Spearman correlation coefficients (r) calculated between the postmetyrapone (PMTP) serum adrenocorticotropic hormone (ACTH), 11-deoxycortisol (11DOC), 11DOC+ cortisol (C) and height, weight, height velocity, weight velocity, change in systolic blood pressure from supine to standing, early morning urinary free cortisol (UFC), morning C, ACTH and dehydroepiandrosterone sulfate (DHEAS). Secondary o

SUBMITTER: Zollner EW 

PROVIDER: S-EPMC3733311 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature