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Complex small-molecule architectures regulate phenotypic plasticity in a nematode.

ABSTRACT: Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.

SUBMITTER: Bose N 

PROVIDER: S-EPMC3733369 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Complex small-molecule architectures regulate phenotypic plasticity in a nematode.

Bose Neelanjan N   Ogawa Akira A   von Reuss Stephan H SH   Yim Joshua J JJ   Ragsdale Erik J EJ   Sommer Ralf J RJ   Schroeder Frank C FC  

Angewandte Chemie (International ed. in English) 20121119 50

Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans. ...[more]

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