CD44 gene polymorphisms in breast cancer risk and prognosis: a study in North Indian population.

ABSTRACT:

Background

Cell surface biomarker CD44 plays an important role in breast cancer cell growth, differentiation, invasion, angiogenesis and tumour metastasis. Therefore, we aimed to investigate the role of CD44 gene polymorphisms in breast cancer risk and prognosis in North Indian population.

Materials & methods

A total of 258 breast cancer patients and 241 healthy controls were included in the case-control study for risk prediction. According to RECIST, 114 patients who received neo-adjuvant chemotherapy were recruited for the evaluation of breast cancer prognosis. We examined the association of tagging SNP (rs353639) of Hapmap Gujrati Indians in Houston (GIH population) in CD44 gene along with a significant reported SNP (rs13347) in Chinese population by genotyping using Taqm

SUBMITTER: Tulsyan S 

PROVIDER: S-EPMC3733640 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature