Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study.

ABSTRACT:

Background

Epidemiologic studies and animal models suggest that in utero arsenic exposure affects fetal health, with a negative association between maternal arsenic ingestion and infant birth weight often observed. However, the molecular mechanisms for this association remain elusive. In the present study, we aimed to increase our understanding of the impact of low-dose arsenic exposure on fetal health by identifying possible arsenic-associated fetal tissue biomarkers in a cohort of pregnant women exposed to arsenic at low levels.

Methods

Arsenic concentrations were determined from the urine samples of a cohort of 133 pregnant women from New Hampshire. Placental tissue samples collected from enrollees were homogenized and profiled for gene expression across a panel of candid

SUBMITTER: Fei DL 

PROVIDER: S-EPMC3733767 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature