Mathematical modelling of spatio-temporal glioma evolution.

ABSTRACT:

Background

Gliomas are the most common types of brain cancer, well known for their aggressive proliferation and the invasive behavior leading to a high mortality rate. Several mathematical models have been developed for identifying the interactions between glioma cells and tissue microenvironment, which play an important role in the mechanism of the tumor formation and progression.

Methods

Building and expanding on existing approaches, this paper develops a continuous three-dimensional model of avascular glioma spatio-temporal evolution. The proposed spherical model incorporates the interactions between the populations of four different glioma cell phenotypes (proliferative, hypoxic, hypoglychemic and necrotic) and their tissue microenvironment, in order to investigate how t

SUBMITTER: Papadogiorgaki M 

PROVIDER: S-EPMC3734056 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature