Differential protein expression in perfusates from metastasized rat livers.

ABSTRACT:

Background

Liver perfusates exhibit theoretical advantages regarding the discovery of disease biomarkers because they contain proteins that readily enter the blood-stream, and perfusion preserves the disease state in its natural context. The purpose of the study is to explore the value of liver perfusate proteome in the biomarker discovery of liver diseases.

Results

In this study, 86 differentially expressed proteins were identified in perfusates from isolated rat livers metastasized by Walker-256 tumor cells. Among these proteins, 27 were predicted to be secreted, and 59 were intracellular or membrane proteins. Most of the secretory proteins (70.4%) were decreased in metastasized liver perfusates. The main canonical ingenuity pathway to which these secretory proteins belong

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3734188 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature