Association analysis between variants in KISS1 gene and litter size in goats.

ABSTRACT:

Background

Kisspeptins are the peptide products of KISS1 gene, which operate via the G - protein-coupled receptor GPR54. These peptides have emerged as essential upstream regulators of neurons secreting gonadotropin-releasing hormone (GnRH), the major hypothalamic node for the stimulatory control of the hypothalamic-pituitary- gonadal (HPG) axis. The present study detected the polymorphisms of caprine KISS1 gene in three goat breeds and investigated the associations between these genetic markers and litter size.

Results

Three goat breeds (n = 680) were used to detect single nucleotide polymorphisms (SNPs) in the coding regions with their intron-exon boundaries and the proximal flanking regions of KISS1 gene by DNA sequencing and PCR-RFLP. Eleven novel SNPs (g.384G>A, g.1147T

SUBMITTER: An X 

PROVIDER: S-EPMC3734198 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature