In vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species.

ABSTRACT:

Background

The present study was designed to investigate the antibacterial activities of the methanol extracts of four Cameroonian edible plants, locally used to treat microbial infections, and their synergistic effects with antibiotics against a panel of twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes expressing active efflux pumps.

Methods

The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of the extracts [alone and in the presence of the efflux pumps inhibitor (EPI) Phenylalanine-Arginine β-Naphtylamide (PAβN)], and those of antibiotics in association with the two of the most active ones, Piper nigrum and Telfairia occidentalis. The preliminary phytochemical screening of the extracts was con

SUBMITTER: Noumedem JA 

PROVIDER: S-EPMC3734210 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature