Transcriptional abundance is not the single force driving the evolution of bacterial proteins.

ABSTRACT:

Background

Despite rapid progress in understanding the mechanisms that shape the evolution of proteins, the relative importance of various factors remain to be elucidated. In this study, we have assessed the effects of 16 different biological features on the evolutionary rates (ERs) of protein-coding sequences in bacterial genomes.

Results

Our analysis of 18 bacterial species revealed new correlations between ERs and constraining factors. Previous studies have suggested that transcriptional abundance overwhelmingly constrains the evolution of yeast protein sequences. This transcriptional abundance leads to selection against misfolding or misinteractions. In this study we found that there was no single factor in determining the evolution of bacterial proteins. Not only transc

SUBMITTER: Wei W 

PROVIDER: S-EPMC3734234 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature