Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.

ABSTRACT:

Background

The mTOR gene regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional single nucleotide polymorphisms (SNPs) may regulate the expression of mTOR and thus contribute to cancer risk.

Methodology/principal findings

In a hospital-based case-control study of 1004 prostate cancer (PCa) cases and 1051 cancer-free controls, we genotyped six potentially functional SNPs of mTOR (rs2536 T>C, rs1883965 G>A, rs1034528 G>C, rs17036508 T>C, rs3806317 A>G, and rs2295080 T>G) and assessed their associations with risk of PCa by using logistic regression analysis.

Conclusions/significances

In the single-locus analysis, we found a signif

SUBMITTER: Li Q 

PROVIDER: S-EPMC3734314 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature