Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation.

ABSTRACT:

Rationale

Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes.

Objectives

To comprehensively define lung microbiota composition during stable disease and exacerbation in patients with bronchiectasis.

Methods

Sputum was collected from patients when clinically stable and before and after completion of antibiotic treatment of exacerbations. Bacterial abundance and community composition were analyzed using anaerobic culture and 16S rDNA pyrosequencing.

Measurements and main results

In clinically stable patients, aerobic and anaerobic bacteria were detected in 40 of 40 (100%) and 33 of 40 (83%) sputum samples, res

SUBMITTER: Tunney MM 

PROVIDER: S-EPMC3734618 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature