IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation.

ABSTRACT: Interleukin-33 (IL-33) is an IL-1 family cytokine that signals via its receptor T1/ST2, and is a key regulator of inflammation, notably the type-2 response implicated in allergic asthma. Critical to our understanding of the role of IL-33 is the identification of the cellular sources of IL-33. Although progress has been made in this area, the development of a robust live cell reporter of expression would allow the localisation of IL-33 during ongoing immune responses. We have generated a fluorescent reporter mouse line, Il33(Cit/+), to define the expression profile of IL-33 in vivo and demonstrate its temporal and spatial expression during experimental allergic asthma responses. We found that type-2 pneumocytes constitute the major source of IL-33 upon allergic lung inflammation following e

SUBMITTER: Hardman CS 

PROVIDER: S-EPMC3734634 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature