The genetic risk of acute seizures in African children with falciparum malaria.

ABSTRACT:

Purpose

It is unclear why some children with falciparum malaria develop acute seizures and what determines the phenotype of seizures. We sought to determine if polymorphisms of malaria candidate genes are associated with acute seizures.

Methods

Logistic regression was used to investigate genetic associations with malaria-associated seizures (MAS) and complex MAS (repetitive, prolonged, or focal seizures) in four MalariaGEN African sites, namely: Blantyre, Malawi; Kilifi, Kenya; Kumasi, Ghana; and Muheza, Tanzania. The analysis was repeated for five inheritance models (dominant, heterozygous, recessive, additive, and general) and adjusted for potential confounders and multiple testing.

Key findings

Complex phenotypes of seizures constituted 71% of all admissions with M

SUBMITTER: Kariuki SM 

PROVIDER: S-EPMC3734649 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature