Genome-wide scan for hypertension linkage to chromosome 12q23.1 - q23.3 in a Chinese family.

ABSTRACT:

Background & objectives

Essential hypertension is a multifactorial disorder with a complex phenotype. Here we report a susceptibility locus for the hypertension mapped by a genome-wide microsatellite scanning in an affected Chinese family, in which 11 members had hypertension before the age of 40.

Methods

A total of 22 individuals from a single family from Shanghai, PR China, were genotyped on more than 400 microsatellite markers with a spacing gap of less than 10 cm for nearly the entire scanned genome.

Results

Linkage analysis suggested that an affected disorder is linked to a locus in the chromosome interval 12q23.1 to 12q23.3; two-point parametric analysis showed a logarithm of odds (LOD) score of 2.97 for the marker D12S346 (12q23.1) and 1.40 for the marker D12S7

SUBMITTER: Dong Y 

PROVIDER: S-EPMC3734686 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature