Directed amination of non-acidic arene C-H bonds by a copper-silver catalytic system.

ABSTRACT: Amine meets arene: A method for direct amination of β-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives.

SUBMITTER: Tran LD 

PROVIDER: S-EPMC3734806 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature