Latent class analysis identifies distinct phenotypes of primary graft dysfunction after lung transplantation.

ABSTRACT:

Background

There is significant heterogeneity within the primary graft dysfunction (PGD) syndrome. We aimed to identify distinct grade 3 PGD phenotypes based on severity of lung dysfunction and patterns of resolution.

Methods

Subjects from the Lung Transplant Outcomes Group (LTOG) cohort study with grade 3 PGD within 72 h after transplantation were included. Latent class analysis (LCA) was used to statistically identify classes based on changes in PGD International Society for Heart & Lung Transplantation grade over time. Construct validity of the classes was assessed by testing for divergence of recipient, donor, and operative characteristics between classes. Predictive validity was assessed using time to death.

Results

Of 1,255 subjects, 361 had grade 3 PGD within t

SUBMITTER: Shah RJ 

PROVIDER: S-EPMC3734891 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature