Molecular markers in prostate cancer. Part I: predicting lethality.

ABSTRACT: Assessing the lethality of 'early,' potentially organ-confined prostate cancer (PCa) is one of the central controversies in modern-day urological clinical practice. Such cases are often considered for radical 'curative' treatment, although active surveillance may be equally appropriate for many men. Moreover, the balance between judicious intervention and overtreatment can be difficult to judge. The patient's age, comorbidities, family history and philosophy of self-health care can be weighed against clinical features such as the palpability of disease, the number and percentage of biopsy cores involved with the disease, histological grade, presenting prostate-specific antigen (PSA) and possible previous PSA kinetics. For many years, scientists and physicians have sought additional molecul

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC3735212 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature