Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.

ABSTRACT:

Objective

Little is known about the genetic etiology of systemic lupus erythematosus (SLE) in individuals of African ancestry, despite its higher prevalence and greater disease severity. Overproduction of nitric oxide (NO) and reactive oxygen species are implicated in the pathogenesis and severity of SLE, making NO synthases and other reactive intermediate-related genes biological candidates for disease susceptibility. We analyzed variation in reactive intermediate genes for association with SLE in 2 populations with African ancestry.

Methods

A total of 244 single-nucleotide polymorphisms (SNP) from 53 regions were analyzed in non-Gullah African Americans (AA; 1432 cases and 1687 controls) and the genetically more homogeneous Gullah of the Sea Islands of South Carolina (133

SUBMITTER: Ramos PS 

PROVIDER: S-EPMC3735344 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature