Fast and accurate fitting of relaxation dispersion data using the flexible software package GLOVE.

ABSTRACT: Relaxation dispersion spectroscopy is one of the most widely used techniques for the analysis of protein dynamics. To obtain a detailed understanding of the protein function from the view point of dynamics, it is essential to fit relaxation dispersion data accurately. The grid search method is commonly used for relaxation dispersion curve fits, but it does not always find the global minimum that provides the best-fit parameter set. Also, the fitting quality does not always improve with increase of the grid size although the computational time becomes longer. This is because relaxation dispersion curve fitting suffers from a local minimum problem, which is a general problem in non-linear least squares curve fitting. Therefore, in order to fit relaxation dispersion data rapidly and accuratel

SUBMITTER: Sugase K 

PROVIDER: S-EPMC3735449 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature