Disruption of anterior insula modulation of large-scale brain networks in schizophrenia.

ABSTRACT:

Background

Systems level modeling of functional magnetic resonance imaging data has demonstrated dysfunction of several large-scale brain networks in schizophrenia. Anomalies across multiple functional networks associated with schizophrenia could be due to diffuse pathology across multiple networks or, alternatively, dysfunction at converging control(s) common to these networks. The right anterior insula has been shown to modulate activity in the central executive and default mode networks in healthy individuals. We tested the hypothesis that right anterior insula modulation of central executive and default mode networks is disrupted in schizophrenia and associated with cognitive deficits.

Methods

In 44 patients with schizophrenia and 44 healthy control subjects, we used see

SUBMITTER: Moran LV 

PROVIDER: S-EPMC3735654 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature