Sequencing of mRNA identifies re-expression of fetal splice variants in cardiac hypertrophy.

ABSTRACT: Cardiac hypertrophy has been well-characterized at the level of transcription. During cardiac hypertrophy, genes normally expressed primarily during fetal heart development are re-expressed, and this fetal gene program is believed to be a critical component of the hypertrophic process. Recently, alternative splicing of mRNA transcripts has been shown to be temporally regulated during heart development, leading us to consider whether fetal patterns of splicing also reappear during hypertrophy. We hypothesized that patterns of alternative splicing occurring during heart development are recapitulated during cardiac hypertrophy. Here we present a study of isoform expression during pressure-overload cardiac hypertrophy induced by 10 days of transverse aortic constriction (TAC) in rats and in de

SUBMITTER: Ames EG 

PROVIDER: S-EPMC3735658 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature