Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Recent guidelines suggest lowering the target blood pressure for patients with chronic kidney disease, although the strength of evidence for this suggestion has been uncertain. We sought to assess the renal and cardiovascular effects of intensive blood pressure lowering in people with chronic kidney disease.

Methods

We performed a systematic review and meta-analysis of all relevant reports published between 1950 and July 2011 identified in a search of MEDLINE, Embase and the Cochrane Library. We included randomized trials that assigned patients with chronic kidney disease to different target blood pressure levels and reported kidney failure or cardiovascular events. Two reviewers independently identified relevant articles and extracted data.

Results

We iden

SUBMITTER: Lv J 

PROVIDER: S-EPMC3735743 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature